K. Richardson

Extracellular granzyme K links inflammatory signaling to nucleotide metabolism, driving epithelial hyperproliferation and reprogramming

Granzymes (Gzms) are a family of serine proteases that have been traditionally studied as cytotoxic mediators of lymphocyte-mediated target cell death. However, increasing evidence suggests that during inflammation Gzms can accumulate in the extracellular milieu and contribute to various pathologies depending on the...