Author

K. Shirakawa

2 papers indexed here

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Open access Aug 2026

Efficient discovery of an agonistic anti-OX40 nanobody by epitope-directed approach to address enrichment-driven epitope bias

Background Conventional antibody discovery approaches that do not account for enrichment-driven biases, such as epitope immunogenicity, PCR amplification bias, or protein expression efficiency, may result in under-representation of rare yet functionally relevant clones, necessitating labor-intensive in vitro screening...

Tomoki Iemura, T. Kitawaki, R. Maeda et al. · Journal for ImmunoTherapy of... · 0 citations

Review Open access Sep 2026

Replication Stress Tolerance in Adult T-Cell Leukemia

Replication stress (RS) represents a major vulnerability of cancer cells treated with nucleoside analogs and related antimetabolites; however, tumors frequently acquire tolerance mechanisms that permit survival despite persistent DNA lesions. This review examines molecular determinants of RS tolerance, focusing on huma...

Yusuke Okamoto, Masayuki Kobayashi, Takashi Sakamoto et al. · Biomolecules · 0 citations