Author

K. Van Keuren-Jensen

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Open access Aug 2026

SALRR: Scalable Analysis of Long-Read RNA-Seq Enables Comprehensive Transcriptome Profiling in Human Brain

Isoform-resolved transcriptomics is fundamental to decoding the molecular complexity of the human brain, yet population-scale long-read RNA sequencing has remained inaccessible due to labor-intensive library preparation, sensitivity to RNA degradation in postmortem tissue, and the absence of integrated, reproducible an...

C. Kouam, Jackson Mingle, Pilar Álvarez Jerez et al. · bioRxiv · 0 citations

Open access Jul 2026

Integrative synaptosome multi-omics reveals disrupted synapse organization and localized cryptic transcripts in C9ORF72-Frontotemporal Dementia

Combined multi-omic profiling of synaptosomes enriched from postmortem frontal cortex and patient-derived induced pluripotent stem cell (iPSC)-derived cortical neurons defines convergent molecular pathways underlying synapse vulnerability in both C9-FTD model systems and identifies synaptic localization of CE-containin...

A. Spillman, E. Alsop, L. M. Gittings et al. · bioRxiv · 0 citations