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Author

K. van Laere

3 papers indexed here

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Open access Aug 2026

Metabolic connectivity alterations in amyotrophic lateral sclerosis: Individual network analysis based on Wasserstein distances

Abstract Molecular connectivity analysis with positron emission tomography (PET) imaging offers a promising approach for characterising brain network alterations in neurodegenerative disorders. In this study, we introduce Wasserstein distance (WD) as an alternative to Kullback–Leibler divergence similarity estimation (...

Chun-Meng Tang, Joke de Vocht, P. van Damme et al. · 0 citations
Open access Sep 2026

Multimodal Retinal Imaging for the Detection of Early Alzheimer’s Disease: Combining Biochemical, Structural, and Vascular Biomarkers

Alzheimer’s disease (AD) pathology is increasingly recognized to manifest in the retina, offering a non-invasive window for early biomarker discovery. This proof-of-concept study investigated whether multimodal retinal imaging—hyperspectral imaging (HSI), optical coherence tomography (OCT), and color fundus photography...

Michiel Ghesquiere, Eirini Christinaki, Sophie Lemmens et al. · 0 citations

Binary classification of 18 F-flutemetamol PET using machine learning: comparison with visual reads and structural MRI

Whether a supervised machine learning technique, support vector machines (SVM), can replicate the assignments made by visual readers blind to the clinical diagnosis, which image components have highest diagnostic value according to SVM and how 18 F-flutemetamol-based classification using SVM relates to structural MRI-bas...

R. Vandenberghe, N. Nelissen, E. Salmon et al. · 0 citations

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