Author

K. Verba

2 papers indexed here

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Aug 2026

Small-molecule activation of the tumor suppressor kinase LKB1 via the pseudokinase STRAD.

The ability to target oncogenic signals has transformed oncology. Targeted therapies typically inhibit oncogenic kinases and GTPases. Therapeutic augmentation of tumor-suppressive signaling could be a viable alternative but poses challenges. Specifically, designing compounds capable of stimulating kinase activity is mo...

Lin Song Kretschmer, Dominique C. Mitchell, Jin Liu et al. · Cell Chemical Biology · 1 citation

Open access Sep 2026

The Chlamydia trachomatis effector CT226 directly engages LRRFIP1 to recruit a multiprotein complex that limits inclusion size and progeny production

The molecular basis and functional consequences of CT226-mediated recruitment of the LFT complex to the inclusion membrane are established and a previously unrecognized role for this effector–host interaction at late timepoints of the C. trachomatis intracellular developmental cycle is uncovered.

C. Elwell, Amy Diallo, B. S. Sixt et al. · mBio · 0 citations