Author

K. Wangensteen

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Open access Sep 2026

Subtyping metabolic dysfunction-associated steatotic liver disease using electronic health record-linked genomic cohorts reveals diverse etiologies and progression

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition with diverse etiologies and clinical presentations. Yet, a consensus of subtypes is lacking in MASLD. Based on latent class analysis of significant MASLD-related clinical variables, we identify five subgroups with distinct gen...

T. Priya, Hui-Huang Yan, K. Wangensteen et al. · Nature Communications · 0 citations

Open access Aug 2026

Multi-ancestry sequencing analysis in 293,141 participants identifies predisposition DNA repair genes associated with HCC risk.

Rare variants in MSH6 and BRCA2 are significantly associated with increased HCC risk, revealing a previously unconfirmed role for DNA repair genes in HCC susceptibility across ancestrally diverse populations and may inform genetic risk stratification and surveillance strategies.

A. Garófalo, Perapa Chotiprasidhi, Josephine P. Johnson et al. · JHEP Reports · 0 citations