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Author

K. Wert

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Review Open access Oct 2026

A Review of PRDM13 Transcriptional Regulation in Vertebrate Retinal Development and Disease

The retina is a complex neuronal tissue whose development from a common retinal progenitor cell population is tightly controlled by a complex gene regulatory network driven by transcription factors. PRDM13 is a transcription factor known to play a critical role in the specification of neurons across the central nervous...

Emily R. Nettesheim, K. Wert · 0 citations
Open access Oct 2026

Female sex accelerates retinal neurodegeneration in Herc3-deficient mice

Retinal degeneration involves mechanisms common to other neurodegenerative diseases, including mitochondrial dysfunction, inflammation, and impaired proteostasis via the ubiquitin-proteasome system (UPS). Although sex hormones modulate these pathways, the molecular basis of this sexual dimorphism remains poorly...

Dogan Can Kirman, Ashley A. Rowe, Ashwani Kumar et al. · 0 citations

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