Author

K. Wicht

2 papers indexed here

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Open access Sep 2026

PCA-mapping and machine learning identify multiple chemotypes with antiplasmodial, β-haematin and haemozoin formation inhibition activity

Inhibiting the formation of haemozoin remains a robust, non-genomic target for antiplasmodial drug discovery. While current efforts focus on multistage active compounds that are not pure haemozoin formation inhibitors, this class offers advantages including selectivity for Plasmodium and is associated with lowered resi...

Nicole Teixeira, Leah Amod, Clinton G. L. Veale et al. · RSC Medicinal Chemistry · 0 citations

#artificial intelligence Review Open access Sep 2026

New thinking for the next generation of antimalarials

Despite decades of intensive research and substantial clinical gains, malaria remains a major global health challenge exacerbated by the continued emergence of drug-resistant strains of the causative agent, Plasmodium parasites. Encouragingly, recent advances in functional genomics, chemical biology and computational s...

Hannah Asiki, Jason Hlozek, K. Wicht et al. · EMBO Molecular Medicine · 0 citations