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Author

K. Worley

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Review Open access Sep 2026

Development of RS1-specific ACMG/AMP variant classification criteria with pilot variant curation

Gene-based therapies are being developed for retinal diseases, including RS1-related X-linked retinoschisis. Therefore it is essential to determine which variants are pathogenic and which are benign when enrolling patients. The Clinical Genome Resource (ClinGen) X-Linked Inherited Retinal Diseases (XLRD) Variant Curati...

Sarah Hull, M. Mero, W. Hankey et al. · 0 citations
Open access Jul 2026

Cross-Species Efficacy of Combinatorial Gene Therapy for Osteoarthritis and Correction of Neuro-Inflammatory Pain Mechanisms

A single intra-articular injection of a combinatorial gene therapy slows OA progression and reduces pain in small and large animal models, and identifies neuroinflammatory signatures for correction of disease progression and pain.

E. Secor, Jun Wang, Zelong Dou et al. · 0 citations

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