Author

K. Z. Guiley

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Open access Sep 2026

Chemical Genetic Targeting of the LRRK2 GTPase Domain

Genetic variants throughout the multi-domain protein leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant Parkinson’s disease, and the most prevalent Parkinson’s-associated LRRK2 variants enhance kinase activity. Hence, the kinase domain has been extensively targeted for therapeutic...

Rachel E. Prorok, Lawrence Y. Zhu, Vickie Bowcut et al. · bioRxiv · 0 citations

Aug 2026

Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology.

Overall, these findings link genetic variation to protein networks and convergent neurodevelopmental dysfunction in ASD.

Belinda Wang, Rasika Vartak, K. Hennick et al. · Science · 1 citation