Author

Kaelan J. Brennan

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Open access Sep 2026

Enhancer Tuning by Sequence-Specific Repressors

Enhancers integrate combinatorial inputs from sequence-specific transcription factors (TFs) and their activity must be calibrated to achieve precise spatiotemporal control of transcript dosage. Here we demonstrate that the sequence-specific repressors SNAI1 and SNAI2 (i.e. SNAIL and SLUG) quantitatively tune enhancer a...

Lucia Ichino, Kaelan J. Brennan, Ben Mallory et al. · bioRxiv · 0 citations

Open access Aug 2026

Cooperativity enables widespread role of low-affinity motifs in chromatin accessibility and increases regulatory potential.

Low-affinity transcription-factor (TF) motifs are an important element of the cis-regulatory code, yet they are notoriously difficult to map and mechanistically incompletely understood, limiting our ability to interpret non-coding variation in development, evolution, and disease. Here, we investigate their role in pion...

M. Weilert, Kaelan J. Brennan, Khyati Dalal et al. · Cell Genomics · 0 citations