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Author

Kai-Hui Sun

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Sep 2026

The BP26-OMP16Es Nanoparticle Vaccine Elicits Protective Immunity against Brucella

This study developed BP26-OMP16Es, a self-assembling nanoparticle vaccine constructed by fusing immunodominant B- and T-cell epitopes from OMP16 to the self-assembling antigen BP26 via flexible linkers, yielding single-copy and double-copy epitope tandem nanoparticles.

Yun-Yi Zhai, Kai-Hui Sun, G. WuDong et al. · 0 citations
Open access Jul 2026

The immune protection of OMP16-specific IgM against Brucella infection.

This study underscores the role of IgM antibodies in combating Brucella infection, offers insights for antibody-based immunotherapy, and provides a theoretical foundation for developing multi-epitope vaccines based on the conserved epitopes and critical residues.

Yun-Yi Zhai, Kai-Hui Sun, Ye Yuan et al. · 0 citations

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