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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Kai Liu

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Sep 2026

Histone Lactylation-mediated PKM2 promotes gemcitabine resistance in pancreatic adenocarcinoma via the AKT/mTOR/SREBP1 Axis.

BACKGROUND Pancreatic adenocarcinoma (PAAD) is a highly malignant tumor. The efficacy of its first-line chemotherapeutic agent, gemcitabine (GEM), is frequently compromised by acquired resistance. Although pyruvate kinase M2 (PKM2) is a potential target for mitigating GEM resistance, the underlying mechanism remains un...

Qing-Hua Yin, Yang Zhou, Kai Liu et al. · 0 citations

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