Abstract Atherosclerosis is a chronic inflammatory and immunometabolic disease in which plaque macrophages integrate lipid-derived danger signals, metabolic stress and cell-death cues to shape foam-cell formation, necrotic-core expansion, fibrous-cap integrity and plaque vulnerability. Moving beyond the conventional M1...
Kai Yang, Shi-Yi Tao, Rui-Kang Liu et al.· Drug Design, Development and...· 0 citations
Dilated cardiomyopathy (DCM) is a major cause of heart failure and cardiovascular mortality, partly due to impaired myocardial energy metabolism. Dietary supplements may offer benefits through improved mitochondrial function and antioxidant effects, and randomized controlled trials (RCTs) suggest they can enhance...
Yi-Ying Liu, Rui-Kang Liu, Jun Li et al.· BMC Cardiovascular Disorders· 0 citations
Background Gut microbiota alterations have been implicated in the progression of metabolic syndrome (MetS), which increases the risk of cardiovascular disease (CVD) and is influenced by lifestyle factors. However, the specific gut microbiota changes and their functional roles in MetS remain incompletely understood. Aim...
Yan-Kun Feng, Kai Yang, Zhuan Qu et al.· Frontiers in Immunology· 0 citations
This study systematically elucidates the potential mechanisms underlying the antihypertensive effects of ZLJYD through multiple components, targets, and pathways, particularly immune regulation and gut microbiota remodeling and provides mechanistic insights into its potential therapeutic application.
Jia-Qi Meng, Chen-Lu Yuan, Ao-Ran Cheng et al.· Computational biology and ch...· 0 citations
An interpretable ML framework identified the immune-metabolic axis as an important predictive component of recent-onset atrial fibrillation in patients with CHF and are inexpensive, clinically accessible biomarkers that may improve early risk stratification and identify a high-risk phenotype characterized by concurrent...
Cheng-Long Yao, Xinmei Liu, Runjia Liu et al.· Frontiers in Endocrinology· 0 citations
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