Demethylzeylasteral Targets the Sp1/AGAP2 Axis to Impair Autophagic Flux and Induce Apoptosis in Hepatic Stellate Cells.
BACKGROUND AND AIM Chronic liver injury-induced liver fibrosis, if left untreated, can progress to cirrhosis or hepatocellular carcinoma, posing a serious threat to human health. Our previous study demonstrated that the natural product demethylzeylasteral (T-96) alleviates liver fibrosis by suppressing ArfGAP with GTPa...