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Kai-Yuan Yang

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Open access Sep 2026

stFormer integrates spatial ligand signaling into a foundation model for spatial transcriptomics.

Recent foundation models for single-cell transcriptomic data generate informative, context-aware gene and cell representations. Spatial transcriptomic (ST) data offer extra positional insights but were not considered by these single-cell models. We introduce stFormer, a transformer model tailored for ST data, which emp...

Sheng-Hao Cao, Kai-Yuan Yang, Jia-Bei Cheng et al. · 0 citations
Open access Jul 2026

SPgen: Proteome-wide Spatial Proteomics generation using multi-modality foundation models

SPgen integrates protein sequences, functional annotations, transcriptomic profiles, and spatial information to learn transferable representations that enable inference beyond experimentally profiled proteins, and accurately reconstructs measured spatial patterns, reduces measurement noise, and enables proteome-wide sp...

Jia-Chen Li, Kai-Yuan Yang, Qiaoling Che et al. · 0 citations

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