Bisphenol A-mediated GPER1/PPARγ/ACC/FAS signaling induces de novo lipogenesis and lipid accumulation in luminal and triple-negative breast cancer cells to regulate epithelial-mesenchymal plasticity.
Enhanced de novo lipogenesis (DNL) is a hallmark of metastatic breast cancer (BC). Environmental exposure to endocrine-disrupting chemicals (EDCs), including bisphenols (such as BPA), is strongly linked to altered lipid metabolism and breast cancer. However, the linkage between EDC-mediated DNL and metastatic transform...