Molecular innate immune programs of tumor-associated macrophages in immune checkpoint blockade resistance: a staged framework from suppressive circuitry to translational bottlenecks
This review discusses TAM-mediated resistance to ICB as a molecularly regulated innate immune process that is dynamic and adaptive, and proposes that future TAM-directed therapies should move beyond broad macrophage depletion or nonspecific suppression and be matched to dominant macrophage programs, informed by spatial...