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Review Open access Aug 2026

An Apparent Diffusion Coefficient-Based Radiomics Tool for Clinically Significant Prostate Cancer Detection in PI-RADS 3 Lesions: A Multicenter Study.

RATIONALE AND OBJECTIVES The clinical management of Prostate Imaging Reporting and Data System (PI-RADS) 3 lesions remains controversial due to their equivocal likelihood of clinically significant prostate cancer (csPCa). This study aimed to develop and validate a prediction model for csPCa detection to assist in clini...

G. Gao, Kexin Wang, Xiao-Ying Wang et al. · 0 citations
Review Open access Sep 2026

Beyond hypoxia and ccRCC: the expanding universe of VHL novel targets and next-generation therapeutics

The von Hippel-Lindau (VHL) gene encodes the core substrate-recognition subunit of the Cullin2-RING E3 ubiquitin ligase complex, regulating cellular oxygen sensing and proteostasis. While targeting the canonical VHL-hypoxia-inducible factor (HIF) axis (e.g. belzutifan) has improved advanced clear cell renal cell carcin...

Rui-Yi Deng, Bo-Yuan Wang, M. Zou et al. · 0 citations

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