Author

Kang Chen

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Review Open access Aug 2026

Harnessing chitosan-based biomaterials for advanced cancer immunotherapy: from nanocarriers to tumor microenvironment modulation

Cancer immunotherapy has transformed oncology, however, its clinical efficacy remains limited by immunosuppressive tumor microenvironments (TMEs), poor therapeutic delivery, systematic toxicity, treatment resistance. Chitosan, a biocompatible and biodegradable polysaccharide, has emerged as a versatile biomaterial capa...

Yun Wang, Yan Fan, Jing Zhang et al. · Journal of Nanobiotechnology · 1 citation

Open access Jul 2026

Self-assembling pH-responsive peptide nanoparticles delivering pyrvinium pamoate induce osteosarcoma senescence through CBX4 ubiquitination-mediated inhibition of YAP1 SUMOylation.

A pH-responsive biomineralization-induced peptide self-assembly nanodelivery system (NP@PP) is developed to improve the druggability of PP and reveals a critical role of the CK1α-CBX4-YAP1 signaling axis in senescence-based osteosarcoma therapy and provides a theoretical and practical basis for the development of new n...

Renyi Zhou, Yue Ma, Xu-Dong Liu et al. · Journal of Nanobiotechnology · 0 citations