Author

Kang Li

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Oct 2026

FPGS drives breast cancer proliferation via CDK9-mediated mitophagy through the mTOR signaling pathway.

Breast cancer remains the leading cause of cancer death among women worldwide, and metabolic reprogramming is increasingly recognized as a hallmark of this disease. Folylpolyglutamate Synthase (FPGS), a key enzyme in folate metabolism, catalyzes the polyglutamylation that retains folate inside cells; however, its role...

Ze-Hao Cai, Han Li, Yang Liu et al. · Cellular Signalling · 0 citations

Open access Jul 2026

GPR19 Drives Cell Cycle Progression via ERK-Dependent FOXM1 Activation in p53-Mutant Breast Cancer.

GPR19 functions as a novel oncogenic driver and clinically relevant biomarker in breast cancer, particularly in TP53-mutant and TNBC subsets, and was significantly upregulated in TP53-mutant breast cancer, primary tumors, and especially TNBC.

Jihan Qiu, Cheng Tian, Hanzhi Li et al. · Frontiers in Bioscience · 0 citations