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Author

Kaori Sano

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Open access Sep 2026

An endonuclease inhibitor unlocks the PA-X shutoff mechanism in influenza A virus.

It is revealed how PA-X modulates the cellular environment while sparing the viral genome to favor viral replication, and while PA-X targets a broad range of RNAs, viral RNAs are protected from its endonuclease activity through their assembly into vRNP complexes.

K. Oishi, Kaori Sano, S. Yamayoshi et al. · 0 citations
Aug 2026

A novel candidate vaccine virus derived from Japan's first mammalian case of clade 2.3.4.4b A/H5N1 highly pathogenic avian influenza virus.

Overall, NIID-002 fulfills the key requirements for the pandemic preparedness of CVV, combining reduced pathogenicity, broad antigenic reactivity, and adequate production efficiency, which underscores the continued need for surveillance and refinement of influenza vaccine strategies to address evolving viral threats.

Yasushi Suzuki, Tomoko Arita, Masayuki Shirakura et al. · 0 citations
Open access Jul 2026

Cross-neutralization of SARS-CoV-2 BA.3.2.2 lineage by JN.1 mRNA vaccine-induced immunity.

BA.3.3.2.2 preserves class 1/2 antibody epitopes, providing a mechanistic basis for cross-neutralization and suggesting a potential therapeutic window for sipavibart should BA.3.3.2.2 expand globally, pending clinical confirmation.

Kei Miyakawa, Kaori Sano, Yohei Seki et al. · 0 citations

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