Abstract Z-DNA is a non-canonical, left-handed nucleic acid conformation implicated in gene regulation and genome instability. Long-read sequencing and telomere-to-telomere genome assemblies now enable analysis of repetitive regions that were absent or incompletely represented in earlier human references. Leveraging T2...
I. Georgakopoulos-Soares, Georgios Megalovasilis, Eleftherios Bochalis et al.· Research Square· 0 citations
G-quadruplexes (G4s) are alternative DNA structures with diverse biological roles, but their examination in highly repetitive parts of the human genome has been hindered by the lack of reliable sequencing technologies. Recent long-read based genome assemblies have enabled their characterization in previously inac...
Nikol Chantzi, Shi Wei. Liew, Aurell Wijaya et al.· Genome Biology· 0 citations
It is demonstrated that HMGB2 is involved in the cellular response to cisplatin treatment by promoting the efficient processing of cisplatin DNA adducts, particularly ICLs, thereby modulating cisplatin sensitivity in human ovarian cancer cells.
Van Huynh, Guliang Wang, Karen M. Vasquez· Genes· 0 citations
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