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Author

Karen M. Vasquez

3 papers indexed here

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Open access Sep 2026

Z-DNA-associated genomic instability in the human pangenome

Abstract Z-DNA is a non-canonical, left-handed nucleic acid conformation implicated in gene regulation and genome instability. Long-read sequencing and telomere-to-telomere genome assemblies now enable analysis of repetitive regions that were absent or incompletely represented in earlier human references. Leveraging T2...

I. Georgakopoulos-Soares, Georgios Megalovasilis, Eleftherios Bochalis et al. · 0 citations
Open access Oct 2026

Landscape and mutational dynamics of G-quadruplexes across the complete human genome

G-quadruplexes (G4s) are alternative DNA structures with diverse biological roles, but their examination in highly repetitive parts of the human genome has been hindered by the lack of reliable sequencing technologies. Recent long-read based genome assemblies have enabled their characterization in previously inac...

Nikol Chantzi, Shi Wei. Liew, Aurell Wijaya et al. · 0 citations
Open access Aug 2026

HMGB2 Impacts Cisplatin-Induced DNA Adduct Processing in Chemoresistant Ovarian Cancer Cells

It is demonstrated that HMGB2 is involved in the cellular response to cisplatin treatment by promoting the efficient processing of cisplatin DNA adducts, particularly ICLs, thereby modulating cisplatin sensitivity in human ovarian cancer cells.

Van Huynh, Guliang Wang, Karen M. Vasquez · 0 citations

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