Karine da Silva Carvalho

Design, larvicidal activity and toxicological assessment of piperine-based amide derivatives against Aedes aegypti (Diptera: Culicidae).

Tetrahydropiperine emerges as a promising scaffold for the development of selective, safe, and effective larvicidal agents by integrating in silico molecular docking and experimental bioassays, and that its saturation enhances larvicidal selectivity while reducing systemic toxicity.