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Author

Karl A. Wessendorf-Rodriguez

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2 papers indexed here

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Open access Sep 2026

Chronic type II interferon promotes tumor growth through mitochondrial RNA-induced type I interferon and prostaglandin synthesis

Interferons are pro-inflammatory cytokines that promote immune cell engagement to eliminate malignant cells. Paradoxically, chronic interferon signaling can also activate anti-inflammatory mechanisms that allow cancer cells to evade the immune system. Here, we sought to determine the cellular mechanisms underlying this...

Melissa A. Johnson, S. Varanasi, K. Mangalhara et al. · 0 citations
Open access Sep 2026

Acetyl-CoA–dependent processes are preferentially supported by local metabolite synthesis

The cell nucleus is an active metabolic site. Numerous enzymes best known for their roles in cytosolic or mitochondrial pathways also function in the nucleus, where they contribute to gene regulation and DNA replication and repair. Although metabolites can diffuse through nuclear pores, it remains unclear the extent to...

Julianna G. Supplee, Pedro Costa-Pinheiro, Karl A. Wessendorf-Rodriguez et al. · 0 citations

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