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Karolina P. Skibicka

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Open access Jul 2026

STING-dependent peripheral inflammaging drives neurodegeneration via extracellular vesicles.

PD represents an accelerated aging disorder driven by STING-dependent inflammation, and LRRK2GoF is identified as a key driver of accelerated aging and systemic inflammaging through DNA-containing EVs, highlighting potential therapeutic targets to counteract inflammaging and neurodegeneration.

M. Öberg, Caitlyn Myers, Najmeh Saffarzadeh et al. · 1 citation