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Karsten Nalbach

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Open access Jul 2026

Spatial multi-omics identifies early synaptic pruning and context-specific dopaminergic vulnerability in synucleinopathies

It is shown that early complement associated pruning of inhibitory synapses precedes overt α-synuclein aggregation and neuronal loss in prodromal synucleinopathy, indicating disease-context dependent relationships between αSyn pathology and neurodegeneration.

Svenja-Lotta Rumpf, Felix L. Struebing, Karsten Nalbach et al. · Nature Communications · 0 citations