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Author

Karthik Rajan Rajamanickam

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Aug 2026

Structural landscape of a wide-open TPP: Insights into extreme conformational plasticity and allosteric potential.

The biochemical and structural characterization of Dermatophilus congolensis TPP is reported, which reveals a moderate catalytic turnover consistent with other bacterial orthologs and suggests a cryptic allosteric site that can be targeted to lock the enzyme in an inert state.

San Kim, Karthik Rajan Rajamanickam, H.-G. Woo et al. · 0 citations

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