Modulation Sterol Regulatory Element-Binding Protein Signaling: Mechanisms, Probes, and Roles in Disease.
Maintenance of lipid homeostasis requires cells to coordinate lipid synthesis precisely. Sterol regulatory element-binding proteins (SREBPs) represent one of the central mechanisms by which cells sense lipid availability and adjust the biosynthesis of fatty acids, cholesterol, and phospholipids in response to metabolic...