Circadian regulation of proteostasis, a key determinant of muscle health, remains poorly understood. Here, we identify DNAJB6, an Hsp40 (DnaJ) co-chaperone, as a substrate of the circadian E3 ligase FBXL21. FBXL21 mediates the ubiquitination-dependent proteasomal degradation of both DNAJB6 and its client proteins, incl...
ABSTRACT Background Cancer cachexia, a debilitating syndrome characterized by muscle wasting, significantly impacts survival in gastrointestinal cancers like pancreatic cancer. Emerging evidence suggests a link between cancer cachexia and disrupted circadian rhythms in peripheral tissues, including locomotor muscles. H...
Jeremy B. Ducharme, Martin M. Schonk, Miguel A. Gutierrez-Monreal et al.· Journal of Cachexia, Sarcope...· 0 citations
It is indicated that sex-specific skeletal muscle exercise adaptations are particularly evident at the PTM level in rats, and future avenues for precision exercise health and medicine are identified.
Gina M. Many, Christopher A. Jin, N. Day et al.· Cell Reports· 0 citations
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