Author

Kasumi Nobuhiro

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Open access Aug 2026

Decay of the Lef1-Srsf3-microRNA axis impairs DNA damage response and underlies stem cell aging

The decay of the Lef1 - Srsf3 -miRNA axis as a core molecular alteration underlying SC aging is defined and revealed that local SC aging may contribute to organismal aging.

Y. Ikuno, Koichiro Watanabe, Y. Kande et al. · Cell Death & Disease · 0 citations

Open access Jul 2026

Royal jelly ameliorates age-associated stem cell dysfunction with Chi3l1-mediated increase in CD206-positive macrophages

It is shown that dietary RJ enhances stem/progenitor cell activity with age- and tissue-dependent Chi3l1 -mediated increases in CD206-positive macrophages, suggesting that Chi3l1 is a physiologically regulated immune mediator, rather than a pathogenic factor in disease contexts, highlighting the importance of mechanis...

Y. Kande, Y. Ikuno, Ayano Narumoto et al. · npj Aging · 0 citations