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Author

Katharina Schäfer

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Sep 2026

Covalent-Allosteric Akt Inhibitors: Targeting Akt3 through Molecular Hybridization and Expanding the Isoform-Selective Toolbox.

Akt is a central serine/threonine kinase in the PI3K/Akt/mTOR pathway that regulates cell survival, growth, and metabolic homeostasis. Although Akt1, Akt2, and Akt3 share high sequence homology, they perform distinct physiological and pathological functions, motivating the development of small-molecule isoform-selectiv...

Kosmas Alexandros Pervanidis, G. D'Angelo, Ioannis Athanasiadis et al. · 0 citations

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