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Author

Katharina Sylvester

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Sep 2026

From Inhibitor to Reporter: Nirmatrelvir-Derived Fluorogenic Substrates for the SARS-CoV-2 Main Protease.

A library of fluorogenic substrates, structurally derived from the well-established Mpro substrate Boc-Abu-Tle-Leu-Leu-Gln-AMC and the clinically approved covalent-reversible Mpro inhibitor nirmatrelvir, was created to optimize assays for highly active Mpro inhibitors by providing Mpro substrates with improved kinetic...

R. Voget, Victoria Steiger, Katharina Sylvester et al. · 0 citations

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