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Katherine C. Fein

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Open access Oct 2026

PEG-associated efficacy loss in lipid nanoparticles persists across formulation modifications for mRNA delivery.

Lipid nanoparticles (LNPs) are clinically proven mRNA delivery vehicles, and repeated administration is often required to maintain therapeutic or prophylactic benefit. However, a single dose can provoke adaptive immune responses against polyethylene glycol (PEG), a polymeric excipient on the LNP surface. In this event,...

Mariah L. Arral, Namit Chaudhary, Katherine C. Fein et al. · 0 citations

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