Author

Katherine S. Given

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Open access Aug 2026

Microglia drive demyelination via multiple sclerosis antibodies and BTK signaling

Inhibition of Bruton’s tyrosine kinase (BTK) limited microglial transcriptional changes and prevented myelin loss following microglial envelopment and support BTK inhibition as a therapeutic strategy to prevent demyelination by modulating microglia behavior.

Lindsay A. Osso, Helena J. Barr, Michael E. Stockton et al. · bioRxiv · 0 citations

Aug 2026

Antibodies against MLC1 found in patients with NMOSD-like disease mediate astrocytopathy in rodent models.

MLC1 antibodies identify a subset of patients with an NMOSD-like phenotype, underscoring their potential as a disease marker with pathogenic relevance.

H. Wong, Samantha Ho, Qian Yu et al. · Science Translational Medici... · 0 citations