Katherine Yaacoub

Isotype specific loss of HP1α but not of HP1β uncovers genomic regions that behave as HP1α-dependent common fragile sites

Data indicate that, independently of its binding to H3K9me3, HP1α stabilizes specific genomic regions that behave as HP1α-dependent fragile sites, at least in part by regulating replication fork progression, limiting mitotic DNA synthesis possibly by competing with FANCD2 for chromatin access at these regions.