Open access
Sep 2026
Incorporation of a pH-Sensitive Linker into Lipid-ASO Conjugates Drives Increased Endosomal Membrane Remodeling Events.
Oligonucleotide therapeutics have great potential for the treatment of previously "undruggable" human diseases; however, their broad utility is limited by challenges in delivery and achieving sufficient endosomal escape. Systemic delivery of antisense oligonucleotides (ASOs) results in their primary accumulation in the...
Priyanka Mangla, Emma Kay, M. J. Munson et al.
· Nucleic Acid Therapeutics · 0 citations