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Author

Kathryn Lande

2 papers indexed here

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Open access Aug 2026

Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling that associates with impaired function of neighboring T cells

Liver cancer incidences increase dramatically beyond 55 years of age, suggesting that age-associated changes contribute critically to tumor initiation. However, the mechanisms linking liver aging and cancer initiation remain incompletely defined. This study investigated the role of CD44, a marker of liver tumor-ini...

Armin Gandhi, Kathryn Lande, K. Li et al. · 0 citations
Open access Sep 2026

Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective

Mitohormesis, whereby transient mitochondrial stress induces adaptive signaling, promotes organismal resilience and longevity in invertebrates, but how this operates in mammals and the underlying metabolic signals involved remain unclear. Using a mouse model of mitohormesis, we show that transient mitochondrial superox...

Matthew P. Donnelly, K. Mangalhara, Yue-Ning Liu et al. · 0 citations

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