X-linked hypophosphatemia (XLH) is a progressive disease in which excess FGF23 causes renal phosphate wasting, leading to hypophosphatemia. Consequences in adults include osteomalacia, fractures, pseudofractures, joint dysfunction, pain, and impaired mobility. Treatments for XLH are the anti-FGF23 antibody burosumab an...
Steven W. Ing, S. Bowden, Kathryn M. Dahir et al.· Journal of Bone and Mineral...· 0 citations
Tumor-induced osteomalacia (TIO) is an ultra-rare, paraneoplastic syndrome caused by tumors secreting fibroblast growth factor 23 (FGF23). In children, TIO may be mistaken for more common causes of rickets and osteomalacia, including monogenic forms, leading to long diagnostic delays. This review aimed to identify evid...
S. Minisola, Suzanne M. Jan de Beur, Thomas O. Carpenter et al.· Calcified Tissue Internation...· 0 citations
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