Katie Nolan

Spectroscopic characterization and co-crystal structure of P450Blt reveal the molecular basis for biarylitide formation.

P450Blt is a cytochrome P450 enzyme (CYP) that forms crosslinked biarylitides by installing an intramolecular aromatic CN bond on a ribosomally synthesized pentapeptide. Closely related CYPs, such as the nitrating enzyme RufO, exhibit distinct catalytic selectivity on the same peptide scaffold. Although both P450Blt an...