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Author

Kaushik V. Amancherla

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Open access Sep 2026

A tRNA-derived small RNA orchestrates cardioprotection through distinct cell-type-specific mechanisms

Pathological cardiac fibrosis and hypertrophy, key contributors to adverse remodeling that drives heart failure (HF), are not adequately targeted by current therapies. We identified tRNA-Asp-GTC-3′tDR, an ischemia-induced tRNA-derived small RNA (tDR), as an endogenous regulator of both remodeling processes across cardi...

Tian Hao, Jin Li, Kaushik V. Amancherla et al. · 0 citations
Open access Aug 2026

Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics

Using spatial transcriptomics on longitudinal human cardiac biopsies, Amancherla, Oill and colleagues reveal marked cellular and molecular heterogeneity in transplanted hearts undergoing rejection, identify gene expression profiles linked to therapy response and outcomes, and show that acute rejection signatures are as...

Kaushik V. Amancherla, A. M. Taravella Oill, Xavier Bledsoe et al. · 1 citation

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