Open access
Aug 2026
Hydration Energetics Shape Antibody Discrimination between Sulfotyrosine and Phosphotyrosine
Chemically similar post-translational modifications can mediate distinct biological functions, but how proteins distinguish between them remains unclear. Sulfotyrosine (sTyr) and phosphotyrosine (pTyr) exemplify this problem because they have similar sizes, local geometries, and electrostatic properties but function in...
Takahiro Mori, Kota Yahagi, Saki Maruoka et al.
· bioRxiv · 0 citations