A novel LncRNA TUG1/miR-30d/e-3p/SNAI2 ceRNA axis drives dermal fibrosis in systemic sclerosis via direct transcriptional activation of COL1A1.
Systemic sclerosis (SSc) is a severe autoimmune disease characterized by progressive dermal fibrosis, aberrant fibroblast activation, and excessive collagen deposition. Although noncoding RNA-mediated regulation has been increasingly implicated in fibrotic diseases, the role of the long noncoding RNA taurine-upregulate...