Ke-Han Ren

Binary-SPA: a reference-free method for cell annotation in high-resolution spatial transcriptomics

Abstract Accurate cell annotation is a primary challenge in spatial transcriptomics (ST). Current approaches primarily rely on label transfer from single-cell RNA sequencing (scRNA-seq) reference or marker-based clustering. While these methods are widely used, they have critical limitations. Label transfer approaches d...

Decoding the erythroid niche: From single-cell programs to spatially resolved architecture in mouse and human hematopoiesis.