N-Stearoyltyrosine Attenuates Ischemia-Reperfusion Injury by Inhibiting Caspase-Dependent Apoptosis and PARP-1/AIF-Mediated Parthanatos.
Cerebral ischemia-reperfusion (I/R) injury induces neuronal death via caspase-dependent apoptosis and parthanatos, a poly (ADP-ribose) polymerase 1 (PARP-1)/apoptosis-inducing factor (AIF)-mediated caspase-independent pathway. Simultaneous inhibition of these pathways may provide enhanced neuroprotection. N-Stearoyltyr...