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Open access Aug 2026

Multi-omics analysis reveals ANAPC1 overexpression and a potential TEAD4-associated regulatory relationship in cholangiocarcinoma

Cholangiocarcinoma (CHOL) is a highly heterogeneous and aggressive malignancy that is frequently diagnosed at an advanced stage because of the lack of early biomarkers, resulting in a poor prognosis. Although ANAPC1 overexpression has been reported in other cancers, its role and regulatory mechanisms in CHOL rema...

Ke-Jun Wu, Lei Wang, Yan-Ting Zhan et al. · 0 citations
Review Open access Sep 2026

Association Between Sleep Disorders and Breast Cancer: An Analysis Based on NHANES and Mendelian Randomization

Background This study aimed to assess the association between sleep disorders and breast cancer (BC) in the National Health and Nutrition Examination Survey (NHANES) and to evaluate potential causal associations using Mendelian randomization (MR), with separate analyses of estrogen receptor-positive (ER+) and estrogen...

Si-Yan Chen, Jian-Di Li, Ke-Jun Wu et al. · 0 citations
Open access Aug 2026

Clinical validation of KIF11 overexpression in colorectal cancer and its potential association with the antitumor effects of nitidine chloride

In vitro and limited xenograft data indicate that NC restrains CRC growth chiefly through the RAD21–KIF11 axis; KIF11 represents a promising preclinical target, though comprehensive systematic in vivo pharmacodynamic and translational animal validation remains absent in the current study and requires further independen...

Hui Li, Rui Lin, Ke-Jun Wu et al. · 0 citations

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