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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Ke-Qin Tan

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Case report Open access Sep 2026

Cadonilimab alone as neoadjuvant immunotherapy followed by radical resection for dMMR/MSI-H gastric adenocarcinoma: a case report

Gastric adenocarcinoma characterized by deficient mismatch repair (dMMR)/high microsatellite instability (MSI-H) represents a distinct subtype with high tumor immunogenicity and inherent sensitivity to immune checkpoint inhibitors. While neoadjuvant dual immunotherapy or chemoimmunotherapy has demonstrated high patholo...

Ke-Qin Tan, Ting-Ting Long, Hong Zhu · 0 citations
Aug 2026

Tumor-intrinsic PHGDH inhibition sensitizes colorectal cancer to PD-1 blockade via α-ketoglutarate-mediated macrophage reprogramming.

Metabolic reprogramming of tumor cells profoundly shapes the tumor microenvironment and contributes to immunotherapy resistance in colorectal cancer (CRC). Here, we identify phosphoglycerate dehydrogenase (PHGDH), a rate-limiting enzyme in de novo serine biosynthesis, as a metabolic regulator of antitumor immunity. In...

Jie-Ping Qiu, Jingwen Wei, Jiaming Liu et al. · 0 citations

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