Daidzein protected against sepsis-induced acute lung injury by suppressing pyroptosis via activation of estrogen receptor-β.
Sepsis-induced acute lung injury (SI-ALI) carries an extremely high mortality rate. Daidzein is a natural phytoestrogen with anti-inflammatory properties. Estrogen receptor β (ERβ) is a potential target for inflammatory regulation. However, whether Daidzein protects against cecal ligation and puncture (CLP)-induced ALI...