While the determination of enzyme kinetic parameters traditionally relies on prolonged and costly experimental methods, machine learning models have recently demonstrated promise as predictive tools. These models still have limitations, such as limited training data and insufficient sensitivity to mutations at import...
Jia-He Qiu, Zong-Ying Lin, Ke-Wei Chen et al.· Journal of Chemical Informat...· 0 citations
Industrial biocatalysis increasingly requires strategies that convert enzyme discovery into robust catalyst systems for process implementation. Here, we report Spatially Programmable Assembly of Computationally Mined Enzymes (SPACE), a sequence-to-scaffold workflow coupling multiparametric enzyme mining with programm...
Qiang Wang, Teng Bao, Jia-He Qiu et al.· ACS Catalysis· 0 citations
A staged view highlights how mechanoadaptive anchoring, redundancy and multifunctionality can contribute to robust infection phenotypes and suggests therapeutic opportunities involving allosteric modulation, decoy-based restoration of host pathways and multi-target biologics.
Guang-Qiang Jia, Ke-Wei Chen, Hai-Jiao Lin et al.· FEMS Microbiology Reviews· 0 citations
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