Author

Ke-Wei Tian

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Review Open access Aug 2026

Epigenetic regulation in medulloblastoma: from tumor heterogeneity to diagnostic, prognostic, and translational applications

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Epigenetic dysregulation, particularly in Group 3 and Group 4 tumors, is a major driver of tumorigenesis despite relatively few recurrent driver mutations. DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs orchestrat...

Xin-Ling Zhang, Lai-Ling Du, Ke-Wei Tian et al. · Frontiers in Molecular Neuro... · 0 citations

Review Open access Sep 2026

Targeted therapy resistance in EGFR-mutant non-small cell lung cancer: Roles of MET, Trop-2-directed antibody–drug conjugates, and molecular monitoring

Introduction: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have substantially improved outcomes in patients with EGFR-mutant non-small cell lung cancer (NSCLC), but acquired resistance remains a major barrier to durable disease control. Objective: This narrative review summarizes the major...

Kai Yan, Ke-Wei Tian, Lai-Ling Du et al. · Eurasian Journal of Medicine... · 0 citations

Open access Aug 2026

Clinical Significance and Changes in Levels of Serum BDNF, mBDNF, AQP4, proBDNF, and GSK3β in Individuals Diagnosed With Bipolar Disorder: A Cross‐Sectional Study

Bipolar disorder (BD) is a severe mood disorder with unclear pathogenesis and limited diagnostic biomarkers. This study aimed to evaluate serum levels of BDNF, mBDNF, AQP4, proBDNF, and GSK3β between BD patients and healthy controls, and to preliminarily explore their potential clinical significance.

Jiawei Zhou, Chun-Ying Zhu, Juezhuo Li et al. · Health Science Reports · 0 citations